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  • Martin, Renee', M.S., Ph.D.
  • Associate Director of Biostatistics
  • Associate Professor of Biostatistics, Department of Public Health Sciences
  • College of Medicine, Medical University of South Carolina
  • Phone: 843-876-1913
  • Fax: 843.876.1923
  • Email: hebertrl@musc.edu
  • Experience: Phase I-III clinical trials; drugs and device trials
  • Research: Covariate imbalance and adaptive randomization in clinical trial designs, application of continual reassessment method in phase I clinical trials, and statistical aspects of interim analysis
  • Projects: Stroke: ischemic, hemorrhagic and subarachnoid hemorrhage; Hypoxic ischemia in neonates and Chorioamnionitis; Aneurysm repair and stroke prevention
Renee Martin, PhD, is Associate Professor of Biostatistics in the Department of Public Health Sciences and the Biostatistics Section Head for the Data Coordination Unit. She has extensive experience and expertise in the planning, implementation and analysis of Phase I-III clinical trials. With emphasis in stroke therapies and aneurysm repair, she serves or has served as an unblinded statistician for several NINDS-sponsored and industry-sponsored. Dr. Martin has served as the primary statistician and statistical PI for the ALISAH, LARGE, ENACT trials and the Phase I trial of N-acetylcysteine in maternal chorioamnionitis to decrease inflammation in the fetal brain and improve neurologic outcomes (CHORIO). Dr. Martin also serves as the primary statistician for the Characterization of Intracranial Atherosclerotic Stenosis using High-resolution MRI (CHIASM) Study and the CTA Spot Sign Score in Acute Cerebral Hemorrhage (SCORE-IT) Study which focus on MRI and/or brain imaging for prediction of clinical outcomes rather than therapeutic interventions, and she has participated as a statistical member of the NINDS-appointed DSMB for the ARUBA trial of arteriovenous malformation and currently serves on the Core DSMB for the NINDS NeuroNEXT projects. Dr. Martin also works collaboratively with DCU faculty/students to publish on methodological issues in clinical trials, such as covariate imbalance and adaptive randomization in clinical trial designs and statistical aspects of interim analysis.

Publications
 
  • Broderick JP, Palesch YY, Demchuk AM, Yeatts SD, Khatri P, Hill MD, Jauch EC, Jovin TG, Yan B, Silver FL, von Kummer R, Molina CA, Demaerschalk BM, Budzik R, Clark WM, Zaidat OO, Malisch TW, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson C, Spilker J, Carrozzella J, Ryckborst KJ, Janis LS, Martin RH, Foster LD, Tomsick TA; Interventional Management of Stroke (IMS) III Investigators.
  • Endovascular therapy after intravenous t-PA versus t-PA alone for stroke.
  • N Engl J Med. 2013 Mar 7;368(10):893-903. doi: 10.1056/NEJMoa1214300. Epub 2013 Feb 7. Erratum in: N Engl J Med. 2013 Mar 28;368(13):1265.
  • Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, Palesch Y, Martin RH, Albers GW, Bath P, Bornstein N, Chan BP, Chen ST, Cunha L, Dahlöf B, De Keyser J, Donnan GA, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, Vandermaelen C, Voigt T, Weber M, Yoon BW; PRoFESS Study Group.
  • Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.
  • N Engl J Med. 2008 Sep 18;359(12):1238-51. doi: 10.1056/NEJMoa0805002. Epub 2008 Aug 27.

Presentations
 
  • Qureshi AI, Foster LD, Martin RL, Palesch YY, for ATACH II Investigators.
  • Analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II Trial by As Treated Groups. (Oral)
  • International Stroke Conference, February 2017.
  • Qureshi AI, Foster LD, Martin RL, Palesch YY, for ATACH II Investigators.
  • Effect of Intensive Systolic Blood Pressure Lowering on Hematoma Expansion in Patients with Intracerebral Hemorrhage: Analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) II Trial. (Oral)
  • International Stroke Conference Nursing Symposium, February 2017.
  • Palesch YY, Ramakrishnan V, Foster L, Martin RL, Cassarly C, Barsan WG, Moy CS, Qureshi AI.
  • Outcome analysis for Antihypertensive Treatment for Acute Cerebral Hemorrhage (ATACH) II Trial using repeated systolic blood pressure measures. (Oral)
  • European Stroke Organization Conference, Prague, May 2017.
  • Ellerbe CN, Martin R.
  • Why undertake clinical trials?
  • August 2014. Third Neurocritical Care Research Conference. Houston, TX. Oral.
  • Ellerbe CN, Martin R.
  • Statistical Methods and CER.
  • August 2014. Third Neurocritical Care Research Conference. Houston, TX. Oral.
  • Palesch YY, Martin RL, Yeatts SD, Durkalski VL.
  • Caution! Approaching Interim Analysis.
  • Presented at the Society for Clinical Trials, Philadelphia, PA, May 2014. Oral presentation.
  • Simpson KN, Simpson AN, Mauldin PD, Hill MD, Yeatts SD, Spilker JA, Foster LD, Khatri P, Martin R, Jauch EC, Kleindorfer D, Palesch YY, Broderick JP.
  • Drivers of Costs Associated with Reperfusion Therapy in Acute Stroke: the IMS III Trial.
  • Presented at the International Stroke Conference, San Diego, CA, February 2014. Oral presentation.
  • Yeatts SD, Martin RH, Foster LD, Woolson RF, Broderick JP, Palesch YY.
  • The Challenges of Decision-Making Regarding Futility in a Randomized Trial: The IMS III Experience.
  • resented at the International Stroke Conference, Honolulu, HI, 2013. Oral presentation.
    *Among the top 10% of accepted abstracts and invited for presentation at Best of AHA Specialty Conferences at Scientific Sessions 2013 in Dallas, Texas.
  • Martin RH, Palesch YY, Zhao W, Dillon C, Qureshi A.
  • Monitoring Treatment Compliance in Large, Multicenter Clinical Trials in Stroke – The ATACH II Experience.
  • European Stroke Conference, London, England, May 2013.
  • Palesch YY, Martin RH, Weng Y, Ramakrishnan V, Yeatts SD
  • Designing a Study for Shift Analysis for Ordinal Data: Application to Acute Stroke Therapy Trials.
  • International Society for Clinical Biostatistics, Munich, Germany, Aug 2013.
  • Martin RH
  • Should We Use Sliding Dichotomy?
  • Second Neurocritical Care research Conference, Houston, Texas, May 2012.
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