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Neurological emergencies remain a distinct, common, and highly morbid category of neurological disorders in which the emergent phase of clinical care often occurs in the pre-hospital setting or Emergency Department (ED) due to the extreme vulnerability of the brain in the early hours of injury. Therefore, identification of early interventions in the ED that optimize the recovery from these injuries to the brain is an important field of research. NETT structure

To that end, the National Institute of Neurological Disorders and Stroke (NINDS) established the Neurological Emergencies Treatment Trials (NETT) Network in 2006 to conduct large simple clinical trials to reduce the burden of acute injuries and illnesses affecting the brain, spinal cord, and peripheral nervous system.

This is a cooperative and highly integrated clinical trials network involving a Statistics and Data Management Center at the DCU, a Clinical Coordinating Center at the University of Michigan, the NINDS, and 17 Hubs at academic medical centers around the country. To date, we have conducted five phase III clinical trials (RAMPART, ALIAS Part 2, ProTECT, POINT, and SHINE) in the NETT.

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